Complement in cancer: untangling an intricate relationship

    • This review summarizes our current understanding of complement-mediated effector functions in the tumour microenvironment, focusing on how complement activation can act as a negative or positive regulator of tumorigenesis.
    • This review offers insight into clinical aspects, including the feasibility of using complement biomarkers for cancer diagnosis and the use of complement inhibitors during cancer treatment.
Author and source information

Authors: Reis ES, Mastellos DC, Ricklin D, Mantovani A, Lambris JD.
Reference: Nat Rev Immunol. 2017 Sep 18. doi: 10.1038/nri.2017.97. [Epub ahead of print] Source: