Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis

  • In mice, C3 is required for maximal periodontal inflammation and bone loss, and for the sustenance of the dysbiotic microbiota.
  • C3 is required  for induction of bone loss in distinct models, including Porphyromonas gingivalis–induced periodontitis, ligature-induced periodontitis, and aging-associated periodontitis.
  • Local treatment of non-human primates (NHPs) with Cp40 inhibits ligature-induced periodontal inflammation and bone loss, which correlates with lower gingival crevicular fluid levels of proinflammatory mediators and decreased osteoclastogenesis in bone biopsy specimens, as compared with control treatment.
  • Conclusion: This study’s findings strongly support the feasibility of C3-targeted intervention for the treatment of human periodontitis. 
Author and source information

Authors: Maekawa T, Abe T, Hajishengallis E, Hosur KB, DeAngelis RA, Ricklin D, Lambris JD, Hajishengallis G.
Reference: J Immunol. 2014 Jun 15;192(12):6020-7. doi: 10.4049/jimmunol.1400569. Epub 2014 May 7.