Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters

Highlights:

• This study uses a refined pre-clinical model of hemodialysis in cynomolgus monkeys to confirm that even modern, polymer-based hemodialysis filters activate complement and to evaluate the potential of Cp40, a peptidic C3 inhibitor, to attenuate hemodialysis-induced complement activation.
• The data show marked induction of complement activation even after only a single session of hemodialysis.
• Complete inhibition of complement activation is achieved in response to two distinct Cp40 treatment regimens.
• Application of Cp40 during hemodialysis results in increased levels of the anti-inflammatory cytokine IL-10.
• Conclusion: Cp40 may be a potent and cost-effective treatment option for attenuating chronic inflammatory conditions in dialysis-dependent patients.